The Hawaii Tumor Registry: more than forty years of cancer surveillance for the islands.

N01 PC035137/PC/NCI NIH HHS/United State

Differential detection of impact site versus rotational site injury by magnetic resonance imaging and microglial morphology in an unrestrained mild closed head injury model.

Seventy-five percent of all traumatic brain injuries are mild and do not cause readily visible abnormalities on routine medical imaging making it difficult to predict which individuals will develop unwanted clinical sequelae. Microglia are brain-resident macrophages and early responders to brain insults. Their activation is associated with changes in morphology or expression of phenotypic markers including P2Y12 and major histocompatibility complex class II. Using a murine model of unrestrained mild closed head injury (mCHI), we used microglia as reporters of acute brain injury at sites of impact versus sites experiencing rotational stress 24 h post-mCHI. Consistent with mild injury, a modest 20% reduction in P2Y12 expression was detected by quantitative real-time PCR (qPCR) analysis but only in the impacted region of the cortex. Furthermore, neither an influx of blood-derived immune cells nor changes in microglial expression of CD45, TREM1, TREM2, major histocompatibility complex class II or CD40 were detected. Using magnetic resonance imaging (MRI), small reductions in T2 weighted values were observed but only near the area of impact and without overt tissue damage (blood deposition, edema). Microglial morphology was quantified without cryosectioning artifacts using ScaleA(2) clarified brains from CX3CR1-green fluorescence protein (GFP) mice. The cortex rostral to the mCHI impact site receives greater rotational stress but neither MRI nor molecular markers of microglial activation showed significant changes from shams in this region. However, microglia in this rostral region did display signs of morphologic activation equivalent to that observed in severe CHI. Thus, mCHI-triggered rotational stress is sufficient to cause injuries undetectable by routine MRI that could result in altered microglial surveillance of brain homeostasis. Acute changes in microglial morphology reveal brain responses to unrestrained mild traumatic brain injury In areas subjected to rotational stress distant from impact site In the absence of detectable changes in standard molecular indicators of brain damage, inflammation or microglial activation. That might result in decreased surveillance of brain function and increased susceptibility to subsequent brain insults

Mode stability in delta Scuti stars: linear analysis versus observations in open clusters

A comparison between linear stability analysis and observations of pulsation modes in five delta Scuti stars, belonging to the same cluster, is presented. The study is based on the work by Michel et al. (1999), in which such a comparison was performed for a representative set of model solutions obtained independently for each individual star considered. In this paper we revisit the work by Michel et al. (1999) following, however, a new approach which consists in the search for a single, complete, and coherent solution for all the selected stars, in order to constrain and test the assumed physics describing these objects. To do so, refined descriptions for the effects of rotation on the determination of the global stellar parameters and on the adiabatic oscillation frequency computations are used. In addition, a crude attempt is made to study the role of rotation on the prediction of mode instabilities.The present results are found to be comparable with those reported by Michel et al. (1999). Within the temperature range log T_eff = 3.87-3.88 agreement between observations and model computations of unstable modes is restricted to values for the mixing-length parameter alpha_nl less or equal to 1.50. This indicates that for these stars a smaller value for alpha_nl is required than suggested from a calibrated solar model. We stress the point that the linear stability analysis used in this work still assumes stellar models without rotation and that further developments are required for a proper description of the interaction between rotation and pulsation dynamics.Comment: 8 pages, 4 figures, 3 tables. (MNRAS, in press

College bound : factors that influence first generation college student process

This qualitative study explores the biopsychosocial factors that influence first-generation Latino students in their decision to attend college, including individuals\u27 demographic characteristics, and how first generation Latino college students cope with changes in their environment when away from home. The fact that only one in ten Latino adults between the ages of 18 and 24 have a college degree (Brindis, Driscoll, Biggs, and Valderrama, 2002) is a staggering number that highlights part of the need for this study. Twelve first generation Latino College students residing in California, Florida, Georgia, North Carolina and New York participated in this research study. They answered open-ended interview questions focusing on the following topics: 1) Biopsychosocial factors influencing first generation Latino students to attend college; 2) Challenges that first-generation Latino students encounter; 3) What helps students to cope more effectively during their first year of college enrollment; and 4) what helps Latino first-generation students to succeed in college. The findings showed that the greatest challenges in being a first generation college student were lack of support from immediate family; lack of information about college; and being of low socioeconomic status. All participants in this study described success as achieving their educational goals in life; helping future first generation college bound students; and being able to maintain financial stability for their own families. The findings also showed that many participants found their transition to the college environment difficult in terms of their individual autonomy and identity as a first generation Latino college student. Many affirmed the importance of having role models and mentors in their communities during their early years in high school to help them visualize college as a real option after attaining a high school diploma. These findings suggest the importance of cultural awareness and the need for improved and accessible resources in communities where Latinos reside. Findings also suggest the need for social workers, educators, and other service providers to become knowledgeable of the strengths and challenge that first generation Latino College students may face in the process of attending college for the first time. Participants also identified resources that are necessary for higher education to implement in order to help first generation Latino students succeed in college

Shaming Citizens: An Ethical Framework for Correcting Citizen Vices

This paper answers the question—can citizens be shamed in a manner that is morally justifiable—by forwarding a theory of just shaming. Shaming has a divisive history in political theory. The volumes of work on both sides seems to point at a moral dilemma: shame looks to be a helpful social practice, yet it engenders unignorable negative consequences. In this paper, however, I argue that shaming in politics must be analyzed more in terms of when and how shaming is morally permissible. Shaming, employed in moments of citizen vice only, has to potential to reform citizen conduct. Furthermore, approaching shaming as more of a dialogue than a punishment can make citizens more amenable to change. Like with “just war” and other non-ideal theories, this paper accepts that politics may permit practices that are normally considered immoral—like shaming—in the pursuit of justice. From here, Eric Beerbohm’s citizen ethics and Iris Marion Young’s “five faces” typology help construct the norm that just shaming will utilize: citizen excellence, or the combatting social oppression actively. Employing this norm, I establish two sets of questions (inspired by just war theory) that will constitute the framework of just shaming. The first, jus ad shaming, asks under what circumstances can citizens be shamed. The second, jus in shaming, asks how someone must act when shaming citizens. From these questions, I construct three conditions—the complicity, activation, and mesomensch conditions—and two guidelines—intent and reciprocity—that delineate how just shaming must be conducted

Review of \u3cem\u3eEmpowering Vulnerable Populations: Cognitive-Behavioral Interventions.\u3c/em\u3e Mary Keegan Eamon. Reviewed Maria Y. Hernandez.

Book review of Mary Keegan Eamon, Empowering Vulnerable Populations: Cognitive Behavioral Interventions. Chicago, IL: Lyceum Press, 2008. $59.95 papercover

Responses in bacterial community structure to waste nutrients from aquaculture: an in situ microcosm experiment in a Chilean fjord

Indexación: Web of Science; Scopus.Chilean salmon farms release inorganic nutrients excreted by the fish into the surrounding water in Patagonian fjords. The objective of this experiment from the Comau Fjord (42.2 degrees S) in southern Chile was to study how increased input of ammonium (NH4) and phosphate (PO4) from salmon farms might affect the community structure of bacteria in surface waters where fish farms are located. We used microcosms (35 l) with NH4-N and PO4-P added to the natural seawater in a gradient of nutrient-loading rates, with the same N: P ratio as in salmon aquaculture effluents. Additionally, we measured bacterial community structure at different depths in the Comau Fjord to assess the natural variation to compare with our experiment. We used denaturing gradient gel electrophoresis (DGGE) to create 16S rDNA fingerprints of the bacterial communities and monitored biological and environmental variables (chlorophyll a, inorganic nutrients, pH, microbial abundance). The nutrient- loading rate had a significant impact on the bacterial community structure, and the community dissimilarity between low and high nutrient additions was up to 78%. Of the measured environmental variables, phytoplankton abundance and increased pH from photosynthesis had a significant effect. We observed no significant changes in bacterial diversity, which remained at the same level as in the unmanipulated community. Thus, the bacterial community of the fjord was not resistant, but resilient within the time frame and nutrient gradient of our experiment.http://www.int-res.com/abstracts/aei/v9/p21-32

Surface mixing and biological activity in the four Eastern Boundary Upwelling Systems

Eastern Boundary Upwelling Systems (EBUS) are characterized by a high productivity of plankton associated with large commercial fisheries, thus playing key biological and socio-economical roles. The aim of this work is to make a comparative study of these four upwelling systems focussing on their surface stirring, using the Finite Size Lyapunov Exponents (FSLEs), and their biological activity, based on satellite data. First, the spatial distribution of horizontal mixing is analysed from time averages and from probability density functions of FSLEs. Then we studied the temporal variability of surface stirring focussing on the annual and seasonal cycle. There is a global negative correlation between surface horizontal mixing and chlorophyll standing stocks over the four areas. To try to better understand this inverse relationship, we consider the vertical dimension by looking at the Ekman-transport and vertical velocities. We suggest the possibility of a changing response of the phytoplankton to sub/mesoscale turbulence, from a negative effect in the very productive coastal areas to a positive one in the open ocean.Comment: 12 pages. NPG Special Issue on "Nonlinear processes in oceanic and atmospheric flows". Open Access paper, available also at the publisher site: http://www.nonlin-processes-geophys.net/16/557/2009

Bacterial Active Community Cycling in Response to Solar Radiation and Their Influence on Nutrient Changes in a High-Altitude Wetland

Indexación: Web of Science; Scopus.Microbial communities inhabiting high-altitude spring ecosystems are subjected to extreme changes in solar irradiance and temperature throughout the diel cycle. Here, using 16S rRNA gene tag pyrosequencing (cDNA) we determined the composition of actively transcribing bacteria from spring waters experimentally exposed through the day (morning, noon, and afternoon) to variable levels of solar radiation and light quality, and evaluated their influence on nutrient recycling. Solar irradiance, temperature, and changes in nutrient dynamics were associated with changes in the active bacterial community structure, predominantly by Cyanobacteria, Verrucomicrobia, Proteobacteria, and 35 other Phyla, including the recently described Candidate Phyla Radiation (e.g., Parcubacteria, Gracilibacteria, OP3, TM6, SR1). Diversity increased at noon, when the highest irradiances were measured (3.3-3.9 H', 1125 W m(-2)) compared to morning and afternoon (0.6-2.8 H'). This shift was associated with a decrease in the contribution to pyrolibraries by Cyanobacteria and an increase of Proteobacteria and other initially low frequently and rare bacteria phyla (< 0.5%) in the pyrolibraries. A potential increase in the activity of Cyanobacteria and other phototrophic groups, e.g., Rhodobacterales, was observed and associated with UVR, suggesting the presence of photo activated repair mechanisms to resist high levels of solar radiation. In addition, the percentage contribution of cyanobacterial sequences in the afternoon was similar to those recorded in the morning. The shifts in the contribution by Cyanobacteria also influenced the rate of change in nitrate, nitrite, and phosphate, highlighted by a high level of nitrate accumulation during hours of high radiation and temperature associated with nitrifying bacteria activity. We did not detect ammonia or nitrite oxidizing bacteria in situ, but both functional groups (Nitrosomona and Nitrospira) appeared mainly in pyrolibraries generated from dark incubations. In total, our results reveal that both the structure and the diversity of the active bacteria community was extremely dynamic through the day, and showed marked shifts in composition that influenced nutrient recycling, highlighting how abiotic variation affects potential ecosystem functioning.http://journal.frontiersin.org/article/10.3389/fmicb.2016.01823/ful